Faculty: Matthew Kay
  
Matthew Kay

 
  Research
Selected Publications
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Research

My research interest is to understand the spatiotemporal dynamics of cardiac electrical activity during normal and disease conditions – with an overall goal of improving heart disease therapies. Fluorescence and electrical imaging of animal hearts (ex-vivo) and two and three dimensional cultures of cardiac cells (in-vitro) is used with custom image and signal processing algorithms to test hypotheses and identify mechanisms of cardiac electrical pathologies. Recent projects have investigated the role of rotor formation in maintaining ventricular fibrillation, electrical vorticity during atrial fibrillation, mechanisms of anti-tachycardia pacing in rabbit hearts and cell cultures, the effect of tissue structure on electrical conduction, and the role of regional ischemia on the induction of ventricular fibrillation.

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Selected Publications

  • Schuessler RB, Kay MW, Melby SJ, Branham BH, Boineau JP, Damiano RJ. Spatial and temporal stability of the dominant frequency of activation in human atrial fibrillation. To appear in J. Electrocardio., 2006.
  • Byrd IA, Kay MW, Pollard AE. Interactions between paced wavefronts and monomorphic ventricular tachycardia: Implications for antitachycardia pacing. To appear in J. Cardiovasc. Electrophysiol., 2006.
  • Kay MW, Walcott GP, Gladden JD, Melnick SB, Rogers JM. Lifetimes of epicardial rotors in panoramic optical maps of fibrillating swine ventricles. To appear in Am. J. Physiol. Heart Circ. Physiol., 2006.
  • Kay MW, Gray RA. Measuring curvature and velocity vector fields for waves of cardiac excitation in 2D media. IEEE Trans. Biomed. Eng., 52(1): 50-63, 2005.
  • Kay MW, Amison PM, Rogers JM. Three-dimensional surface reconstruction and panoramic optical mapping of large hearts. IEEE Trans. Biomed. Eng., 51(7): 1219-1229, 2004.
  • Nanthakumar K, Walcott GP, Melnick S, Rogers JM, Kay MW, Smith WM, Ideker RE, Holman W. Epicardial Organization of Human Ventricular Fibrillation. Heart Rhythm, 1(1): 14-23, 2004.
  • Kay MW, Rogers JM. Mapping a moving target. J. Cardiovasc. Electrophysiol., 14(10): 1085-1086, 2003.
  • Qin H, Kay MW, Chattipakorn N, Redden DT, Ideker RE, Rogers JM. E ects of heart isolation voltage-sensitive dye, and electromechanical uncoupling agents on ventricular brillation. Am. J. Physiol. Heart Circ. Physiol., 284: H1818-H1826, 2003.
  • Kay MW, Bayly PV, Schuessler RB. E ects of measurement error and sampling resolution on estimates of atrial tissue recovery parameters. Ann. Biomed. Eng., 28: 677-690, 2000.
  • Kay MW, Roe SC, Stikeleather LF, Mahmoud A, Abrams Jr., CF. Axial vibration of threaded external fixation pins: Detection of pin loosening. Ann. Biomed. Eng., 26: 361-368, 1998.
  • Lin PP, Roe SC, Kay MW, Abrams CF, Jr., Jones AR. Placement of screws in the sustentaculum tali: An experimental model of calcaneal fractures. Clin. Ortho. Rel. Res., 352: 194-201, 1998.

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Assistant Professor of Engineering and Applied Science,
Assistant Professor of Pharmacology and Physiology
Office: Phillips Hall 619
Phone: 202-994-6083, Fax: 202 994-0227

Lab: Ross Hall 456
Lab Phone: 202-994-0621
Email: phymwkATgwu.edu

B.S.M.E. 1993, North Carolina State University, NC
M.S.B.E. 1996, North Carolina State University, NC
D.S.B.M.E. 2000, Washington University in St. Louis, MO